From cornell university mechanical engineering 6240 physics of micro and nanoscale fluid mechanics 10 sep 2012. Using the commercial finite element package comsol multiphysics, it guides researchers on how to predict the particle transport subjected to electric fields in micronanoscale channels. There has recently been widespread interest in the use of ac electric. Due to the local ion depletion near micro nanofluidic junction, significantly. Jin xz, joseph s et al 2007 induced electrokinetic transport in micronanofluidic interconnect devices.
Viscoelastic effects on electrokinetic particle focusing. With the recent advancement in micro fabrication technology, labonachip devices have been developed in order to perform biological analysis through cell manipulation. The system considered is a nanochannel connected with two microchannels at its ends. The investigation of electrokinetic particle transport in confined microchannels has practical significances in a variety of applications ranging from traditional gel electrophoresis to electrokinetic microfluidicsbased labonachip devices. The electrokinetic phenomena were characterized by microparticle image. With the recent advancement in microfabrication technology, labonachip devices have been developed in order to perform biological analysis through cell manipulation. Jun yang, fuzhi lu, larry w kostiuk and daniel y kwok. When the solidliquid interface acquires a surface charge, an electrical double layer is formed as ions in the electrolyte solution align preferentially based on their charge. Meinhart department of mechanical and environmental engineering, ucsb. A new micro valve using the electrokinetic motion of a janus particle is introduced in this paper. Electrokinetic transport in micronanofluidic systems with. This text was designed with the goal of bringing together several areas that are often taught separately namely, fluid mechanics, electrodynamics, and interfacial chemistry and electrochemistry. Bhattacharyya department of mathematics indian institute of technology, kharagpur 722, india.
Numerous applications of micro nanofluidics are related to particle transport in micro nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro nanofluidics. Electrokinetic transport processes such as electroosmosis, induced. Electrohydrodynamics ehd, also known as electrofluiddynamics efd or electrokinetics, is the study of the dynamics of electrically charged fluids. In this edition, page numbers are just like the physical edition. Trapping of submicron and micronsized particles using. Focusing suspended particles in a fluid into a single file is often important and necessary in order to continuously detect, analyze, and sort them for numerous applications.
Electrokinetic microfluidic device free download as powerpoint presentation. The electrokinetic motion of the particles and cells refers to. Electrokinetic transport in nanofluidics has attracted many attentions in recent years due to its potential applications in biomedical analysis and energy conversion systems. To date, however, studies on particle electrokinetics have been limited to primarily theoretical or numerical analyses in straight. Download electrokinetic particle transport in micronano. Numerous applications of micronanofluidics are related to particle transport in micronanoscale channels, and electrokinetics has proved to. Electrokinetic particle transport in micronanofluidics direct. Home research electrokinetic phenomena for an enhanced understanding of ongoing atomic force microscopy afm measurements, i have been working on the numerical modeling of the afm tip 5nm interacting with a flat substrate immersed in an ionic solution. Both micrometerresolution particle image velocimetry micropiv and particle tracking velocimetry ptv techniques have been used to quantify and study flow phenomena in electrokinetic systems applicable to microfluidic bioanalytical devices. To date, however, studies on particle electrokinetics have been limited to primarily theoretical or numerical analyses in straight microchannels of.
Electrokinetic particle transport in micro nanofluidics. Using the commercial finite element package comsol multiphysics, it guides researchers on how to predict the particle transport subjected to electric fields in micro nanoscale channels. The biggest challenge to model the electrokinetic transport using atomistic simulations is the extensive cost in calculation of the longrange electrostatic force between. It is the study of the motions of ionized particles or molecules and their interactions with electric fields and the surrounding fluid. Download pdf nanofluidics and microfluidics free online. Electrokinetic particle transport in micronanofluidics. In recent applications with dnas, proteins, or microorganisms, particles can deform. Electrokinetic transport phenomena in microfluidics. This classical theory was established decades ago in wellestablished disciplines. Selective transport of ions though nanochannels induce ion concentration polarization. We have applied particle tracking techniques to obtain spatially resolved velocity measurements in electrokinetic flow devices. Twovolume set comprehensively captures the crossdisciplinary breadth of the fields of micro and nanofluidics, which encompass the biological sciences, chemistry, physics and engineering applications. Field effect control of electrokinetic transport in micro nanofluidics.
Jan 03, 2012 the modulation of the surface potential at the channelliquid interface can also affect the electrokinetic transport of fluids and particles. A janus particle with a conducting hemisphere and a nonconducting hemisphere is placed in a junction of several microchannels. Electrokinetic flow and measure method in microfluidic. The flow control is observed at relatively low gate voltage less than 50 v, and this local flow control is primarily due to current leakage through the interface between pdms and glass layers. This text focuses on the physics of fluid transport in micro and nanofabricated liquidphase systems, with consideration of gas bubbles, solid particles, and macromolecules. Field effect control of particle electrokinetic transport in micronanofluidics due to the full coupling of the fluid and particle dynamics, electrostatics, and ionic mass transport described by the model in section 2. Microvalve using inducedcharge electrokinetic motion of.
These can be utilized for flow, species and particle transport control applications in microfluidic systems. There has been a growing interest in developing onlabachip micronanofluidic systems for biodetection, biotechnology, chemical and biological reactors, and medical. They are routinely used to sense and measure properties of single molecules such as dna. Freesurface problems in electrokinetic micro and nanofluidics. Both micrometerresolution particle image velocimetry micro piv and particle tracking velocimetry ptv techniques have been used to quantify and study flow phenomena in electrokinetic systems applicable to microfluidic bioanalytical devices. Download it once and read it on your kindle device, pc, phones or tablets. Electrokinetic microchannel battery by means of electrokinetic and microfluidic phenomena. We start with an introduction into the theoretical basis of ion transport kinetics and their analogy. Electrokinetic properties of microfluidic substrates funding.
Published 20 october 2003 journal of micromechanics and microengineering, volume, number 6. Molecular simulation of electrokinetic transport in. Electrochemical analysis based on nanoporous structures. Field effect control of particle electrokinetic transport in m icronanofluidics due to the full coupling of the fluid and particle dynamics, electrostatics, and ionic mass transport described by the model in section 2. Electrokinetic manipulation of particles and cells in. Electrokinetic effects here we introduce the reader to electrostatics in liquids and electrokinetic effects, which are the most important and fundamental concepts for the description of transport in nano. The fundamental theory of the electrokinetic flow and ion transport in micro and nanofluidics.
The book emphasizes the direct numerical simulation of electrokinetic particle transport phenomena, plus several supportive experimental studies. In this study, electrokinetic transport in a micronanofluidic system is numerically investigated by solving the transient poisson, nernstplanck, and navierstokes equations simultaneously. Under an applied electric field, the inducedcharge electrokinetic flow around the. Numerous applications of micronanofluidics are related to particle transport in micronanoscale channels, and electrokinetics has proved to be one of the.
Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micro nanofluidics involving electrophoresis, dielectrophoresis, electroosmosis, and inducedcharge electroosmosis. It is safe to conclude that the middle part of the microchannel is suitable for processing some neutral particles. The analytical solutions indicate that pressuredriven flow of an electrolyte solution in microchannel with charged solid wall induces a streaming. Modeling electrokinetic phenomana in micro and nanofluidics. Iutam symposium on advances in micro and nanofluidics electronic resource.
Pdf electrokinetic motion of particles and cells in microchannels. Download nanofluidics and microfluidics ebook pdf or read online books in pdf, epub. Electrokinetic flow control in microfluidic chips using a. Therefore, a comprehensive understanding of electrokinetic particle transpo. The particle motion is in general unknown a priori, and so its location as well as translational and rotational velocity are to be determined in a coupled manner with the electrokinetic flow. Rectification of ionic current in a nanofluidic diode. Field effect control of electrokinetic transport in micro. Soft lithography technique is used to form microchannels on polydimethyl siloxane pdms, while a glass slide or thin pdms layer is used to cover the microchannels. Nanopores are apertures of nanometric dimensions in an insulating matrix. These can be utilized for flow, species and particle transport control applications in micro fluidic systems. Electrokinetic transport is increasingly utilized in micro nanofluidic applications due to its ability to manipulate fluids, ions, and bio particles using only electric fields without moving. The book emphasizes the direct numerical simulation of.
Electrokinetic based microflows are studied both experimentally and theoretically. Corresponding comsol script files are provided with. Article pdf available in microfluidics and nanofluidics 64. The modulation of the surface potential at the channelliquid interface can also affect the electrokinetic transport of fluids and particles. In smallscale microfluidics processes, electroosmosis, electrothermal effects, and electrokinetic instabilities are responsible for fluid motion and electrophoresis and dielectrophoresis dep cause particle movement, such as in cells. Doe, lockheed martin, cornell, acsprf among the unique properties of microfluidic devices is the ability to move liquids via electroosmosis. Highthroughput particle manipulation by hydrodynamic. Fabrication of microchannels and associated electrodes to generate. A new microvalve using the electrokinetic motion of a janus particle is introduced in this paper. To fill the knowledge gap between engineering and the basic.
Highthroughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated micro. Field effect control of electrokinetic transport in micronanofluidics. Oct 26, 2010 electrokinetic transport in nanofluidics has attracted many attentions in recent years due to its potential applications in biomedical analysis and energy conversion systems. We start with an introduction into the theoretical basis of ion transport kinetics and their analogy to the charge transport in electronic systems. Microchannels used in these labonachip devices have been demonstrated to accurately perform many different cell manipulation techniques such as focusing, separation, trapping, and lysis. An analytical solution for pressuredriven electrokinetic flows in a narrow capillary is presented based on the poissonboltzmann equation for electrical double layer and the navierstokes equations for incompressible viscous fluid.
Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micronanofluidics involving electrophoresis, dielectrophoresis, electroosmosis, and inducedcharge electroosmosis. Simulating electrokinetic phenomena in microfluidics. Numerous applications of micronanofluidics are related to particle transport in micronanoscale channels, and electrokinetics has proved to be one of the most. Electrokinetic transport of ions between electrolyte solutions and ion. Electrokinetic coupling matrix onsager kinetic matrix. Electrokinetic flow diagnostics stanford university. The term may be considered to be synonymous with the rather elaborate electrostrictive hydrodynamics. Dear colleagues, micronanofluidic chips have found increasing applications in the analysis of chemical and biological samples over the past two decades. Modeling electrokinetic phenomana in micro and nanofluidics s. Electrokinetic phenomena in pencil leadbased microfluidics mdpi. Electrokinetic ion transport in nanofluidics and membranes with. Electrokinetically driven microfluidics and nanofluidics electrokinetics is currently the mechanism of choice for. Numerical analysis of electrokinetic transport in micro.
Letter electrokinetic flow in the ushaped micronanochannels. I basic principles and linear beam dynamics ii nonlinear and higherorder beam dynamics springer berlin heidelberg professor dr. This text was designed with the goal of bringing together several areas that are often taught separately namely, fluid mechanics, electrodynamics, and interfacial chemistry and electrochemistry with a focused goal of. Direct numerical simulation analysis surfactant science book 153 kindle edition by qian, shizhi, ai, ye. The term may be considered to be synonymous with the rather elaborate electrostrictive. Use features like bookmarks, note taking and highlighting while reading electrokinetic particle transport in micronanofluidics. Yang school of mechanical and aerospace engineering, nanyang technological university, singapore abstract microfluidic manipulation of particulate matters has found its applications in cell handling, virus detection, biomolecule concentration and colloidal particle.
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